CARACTERÍSTICAS Y FACTORES DE RIESGO PARA MORTALIDAD EN PACIENTES HOSPITALIZADOS POR COVID -19 EN UN HOSPITAL PUBLICO EN TACNA

Miguel  Hueda Zavaleta; Cesar Augusto Copaja Corzo; Fabrizzio  Bardales Silva; Rodrigo Flores Palacios; Luis Barreto Rocchetti; Vicente Aleixandre  Benites Zapata

doi:10.1590/SciELOPreprints.1764

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Miguel Hueda Zavaleta Universidad Privada de Tacna, Facultad de Ciencias de la Salud. Tacna, Perú https://orcid.org/0000-0002-8049-7787
Cesar Augusto Copaja Corzo Centro de Investigación de Estudiantes de Medicina https://orcid.org/0000-0002-3497-0158
Fabrizzio Bardales Silva Hospital III Daniel Alcides Carrión – EsSalud Tacna. Tacna, Perú https://orcid.org/0000-0001-9020-4426
Rodrigo Flores Palacios Hospital III Daniel Alcides Carrión – EsSalud Tacna. Tacna, Perú https://orcid.org/0000-0001-5374-7915
Luis Barreto Rocchetti Hospital III Daniel Alcides Carrión – EsSalud Tacna. Tacna, Perú https://orcid.org/0000-0002-2851-0219
Vicente Aleixandre Benites Zapata Universidad San Ignacio de Loyola, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Lima, Perú

DOI:

https://doi.org/10.1590/SciELOPreprints.1764

Keywords:

COVID-19, viral pneumonia, coronavirus infections, mortality, Peru, colchicine

Abstract

ABSTRACT

Objective: The objective of the study was to describe the clinical, laboratory and treatment characteristics of patients hospitalized for COVID-19 and to determine the risk factors for hospital mortality.

Methods: Retrospective cohort study of adult patients hospitalized for COVID-19. Clinical, laboratory and treatment data were extracted from the medical records of patients admitted to Level III Daniel Alcides Carrión-Tacna Hospital. Survival analysis used the Cox proportional hazards model and crude and adjusted hazard ratios (HR) were calculated with their respective 95% confidence intervals (95% CI).

Results: 351 patients were evaluated, 74.1% were men, the most common comorbidities were obesity (31.6%), hypertension (27.1%) and diabetes mellitus (24.5%). The median time of hospitalization was 8 days (IQR: 4-15). 32.9% died during follow-up. The multivariate analysis showed an increased risk of dying associated with age> = 65 years HR = 3.55 (95% CI: 1.70-7.40), increase in lactate dehydrogenase> 720 U / L HR = 2.08 (95% CI: 1.34-3.22), and oxygen saturation less than 90%, mainly when it was less than 80% RH = 4.07 (95% CI: 2.10-7.88). In addition, within the treatment, colchicine showed a protective effect HR = 0.46 (95% CI: 0.23-0.91).

Conclusions: Risk factors for mortality from COVID-19 included being older than 65 years, having oxygen saturation less than 90%, and elevated lactate dehydrogenase> 720 U / L; colchicine treatment could improve the prognosis of patients.