Tratamento da Leucemia Linfocítica Crônica (LLC) com Obinutuzumabe e Venetoclax: Um Estudo de caso

William Mário de Carvalho Nunes; Raquel Pantarotto Souza; Matheus Corazza Nunes; Sarah Pagliarini e Silva

doi:10.1590/SciELOPreprints.11563

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William Mário de Carvalho Nunes State University of Maringá https://orcid.org/0000-0003-3445-5487
Raquel Pantarotto Souza State University of Maringá https://orcid.org/0000-0002-4124-033X
Matheus Corazza Nunes Centro Universitário Cesumar https://orcid.org/0000-0003-3445-5487
Sarah Pagliarini e Silva State University of Maringá https://orcid.org/0000-0003-2740-0795

DOI:

https://doi.org/10.1590/SciELOPreprints.11563

Keywords:

Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cel, Therapeutics

Abstract

Chronic Lymphocytic Leukemia (CLL) is a hematologic neoplasm that primarily affects elderly individuals, caused by the monoclonal expansion of neoplastic B lymphocytes. Recent advances in the understanding of CLL pathophysiology have led to the development of more targeted and effective therapies, such as Obinutuzumab and Venetoclax. Thus, the objective of this study was to report the case of a patient diagnosed with CLL and treated with a combination of Obinutuzumab (six cycles) and Venetoclax (twelve cycles) to raise awareness of this neoplasm and a successful treatment option, promoting knowledge and healthcare benefits for the population. Periodic blood counts were performed to monitor treatment progress, which was considered successful in the end, with leukocyte counts maintained within normal ranges. It is concluded that the combination of Obinutuzumab and Venetoclax is a promising therapeutic strategy for patients with CLL.

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Author Biographies

William Mário de Carvalho Nunes, State University of Maringá

Associate Professor at the State University of Maringá (UEM), until 2023. In August 2023 he became Senior Researcher in the Postgraduate Program in Agronomy at UEM (PGA/UEM). He has a degree in Agronomy from the State University of Maringá (1984), a master's degree in Phytopathology - Agronomy - from ESALQ/USP (1994) and a PhD in Plant Protection-Agronomy from UNESP (1999). He completed his Post-Doctorate at the Citriculture Center - IAC (2009). Consultant for the journals Plant Disease, European Journal of Plant Pathology, Archives of Phytopathology and Plant Protection, Tropical Plant Pathology, Summa Phytopathologica, Acta Scientiarum and Citrus Research and Technology. He has experience in the area of Agronomy, with an emphasis on Phytopathology, working mainly on the topics of epidemiology and molecular biology of citrus diseases: citrus canker, citrus variegated chlorosis, huanglongbing (ex-greening), early blight and citrus sadness virus. In October 2020, he took over as head of the Department of Agronomy at the Center for Agricultural Sciences at UEM. President of the HUB Agronomy Association of the State University of Maringá, elected in December 2023. In 2024 he began the undergraduate course in Accounting Sciences at the State University of Maringá.

Raquel Pantarotto Souza, State University of Maringá

Atualmente é professora do Departamento de Análises Clínicas e Biomedicina da Universidade Estadual de Maringá, ministrando as disciplinas em Análises Clínicas (Hematologia Clínica e Citologia Clínica). Pós-Doutora pela Universidade Estadual de Maringá, Brasil (2018). Doutora em Biociências e Fisiopatologia pela Universidade Estadual de Maringá, Brasil (2016). Mestre em Biociências Aplicadas à Farmácia pela Universidade Estadual de Maringá, Brasil (2012). Graduação em Farmácia com habilitação em Análises Clínicas pela Universidade Estadual de Maringá, Brasil (2010).

Matheus Corazza Nunes, Centro Universitário Cesumar

Possui graduação em Medicina pelo Centro de Ensino Superior de Maringá (2019). Concluiu a Residência Médica em Área Básica Cirúrgica em 2022. Durante a pandemia do COVID, em 2020 e 2021, atuou em atendimento na linha de frente em enfermarias e UTIs. Tem experiência na área de Medicina, com ênfase em Cirurgia Geral, área que mais se identifica. Atualmente fazenda a residëncia médica no Unicesumar na área de Coloproctologia.

Sarah Pagliarini e Silva , State University of Maringá

Possui graduação em Medicina pela Universidade Estadual de Maringá (2005). Fez residência médica em Clínica Médica, Hematologia e Hemoterapia na Universidade de São Paulo (2008). Concluiu mestrado no Centro de Ciências da Saúde, programa de Biociências Aplicadas a Farmácia, da Universidade Estadual de Maringá (2011). Atualmente trabalha é sócia fundadora da ELO Oncologia Integral e ELO Clinical Research (Pesquisa Clínica). Trabalha como hematologista no Hospital Paraná - Unidade Oncológica e Santa Casa de Misericórdia de Maringá.