Preprint / Version 1

Multisystem Inflammatory Syndrome in Children: sectional study of cases and factors associated with deaths during COVID-19 pandemic in Brazil, 2020

##article.authors##

  • Laís de Almeida Relvas-Brandt Secretaria de Vigilância em Saúde https://orcid.org/0000-0003-1273-5445
  • Caroline Gava Secretaria de Vigilância em Saúde https://orcid.org/0000-0001-6287-1715
  • Fernanda Sindeaux Camelo Secretaria de Vigilância em Saúde https://orcid.org/0000-0002-1680-2310
  • Victor Bertollo Gomes Porto Secretaria de Vigilância em Saúde https://orcid.org/0000-0002-3112-6154
  • Ronaldo Fernandes Santos Alves Secretaria de Vigilância em Saúde https://orcid.org/0000-0002-8358-0519
  • Marcela Santos Correa Da Costa Secretaria de Vigilância em Saúde
  • Sandra Maria Deotti Carvalho Secretaria de Vigilância em Saúde
  • Greice Madeleine Ikeda do Carmo Secretaria de Vigilância em Saúde
  • Francieli Fontana Sutile Tardetti Fantinato Secretaria de Vigilância em Saúde https://orcid.org/0000-0002-0110-2266
  • Marcelo Yoshito Wada Secretaria de Vigilância em Saúde
  • Yluska Myrna Meneses Brandão e Mendes Secretaria de Vigilância em Saúde
  • Martha Gonçalves Vieira Secretaria de Atenção Primária à Saúde
  • Roselle Bugarin Steenhouwer Secretaria de Atenção Primária à Saúde https://orcid.org/0000-0002-3776-2979
  • Klebia Magalhães Pereira Castello Branco Sociedade Brasileira de Cardiologia
  • Maria Verônica Câmara dos Santos Sociedade Brasileira de Cardiologia
  • Ivan Romero Rivera Sociedade Brasileira de Cardiologia https://orcid.org/0000-0001-9473-132X
  • Luiz Henrique Nicoloso Sociedade Brasileira de Cardiologia
  • Marco Aurelio Palazzi Safadi Sociedade Brasileira de Pediatria https://orcid.org/0000-0002-4401-9446
  • Dalva Maria de Assis Sociedade Brasileira de Pediatria https://orcid.org/0000-0002-3102-7607

DOI:

https://doi.org/10.1590/s1679-49742021000400005

Keywords:

Coronavirus Infections, Pediatrics, Systemic Inflammatory Response, Syndrome, Death, Epidemiological Monitoring, Cross-Sectional Studies

Abstract

Objective: To describe the clinical-epidemiological profile of Multisystem Inflammatory Syndrome in Children (MIS-C) cases and to identify factors associated with MIS-C deaths in Brazil, 2020. Methods: Cross-sectional study, based on MIS-C national monitoring database in Brazil, 2020. Simple and multiple logistic regression was performed to estimate crude and adjusted odds ratios (OR). Results: The median age of cases (n=652) was 5 years, 57.1% were male, 52.0% were brown race/color and 6.4% died. The odds of death was greater among those who presented O2 saturation <95% (ORa=4.35 – 95%CI 1.69;11.20) and altered result of urea (ORa=5.18 – 95%CI 1.91;14.04); lower in the absence of cutaneous lesion such as rash (ORa=0.23 – 95%CI 0.09;0.62), with the use of anticoagulants (ORa=0.32 – 95%CI 0.12;0.89) and of immunoglobulins (ORa=0.38 – 95%CI 0.15;1.01). Conclusion: Fatality rates was higher among cases that presented O2 saturation<95% and altered urea, and lower among those with cutaneous lesion, who used immunoglobulins and anticoagulants.

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Posted

09/20/2021

How to Cite

de Almeida Relvas-Brandt, L. ., Gava, C. ., Sindeaux Camelo, F. ., Bertollo Gomes Porto, V. ., Fernandes Santos Alves, R. ., Santos Correa Da Costa, M. ., Maria Deotti Carvalho, S. ., Madeleine Ikeda do Carmo, G. ., Fontana Sutile Tardetti Fantinato, F. ., Yoshito Wada, M. ., Myrna Meneses Brandão e Mendes, Y. . ., Gonçalves Vieira, M. ., Bugarin Steenhouwer, R. ., Magalhães Pereira Castello Branco, K. ., Câmara dos Santos, M. V. ., Romero Rivera, I. ., Nicoloso, L. H. ., Palazzi Safadi , M. A. ., & Maria de Assis, D. . (2021). Multisystem Inflammatory Syndrome in Children: sectional study of cases and factors associated with deaths during COVID-19 pandemic in Brazil, 2020. In SciELO Preprints. https://doi.org/10.1590/s1679-49742021000400005

Section

Health Sciences