Preprint / Version 1

Multisystem Inflammatory Syndrome in Children: sectional study of cases and factors associated with deaths during COVID-19 pandemic in Brazil, 2020

##article.authors##

  • Laís de Almeida Relvas-Brandt Secretaria de Vigilância em Saúde https://orcid.org/0000-0003-1273-5445
  • Caroline Gava Secretaria de Vigilância em Saúde https://orcid.org/0000-0001-6287-1715
  • Fernanda Sindeaux Camelo Secretaria de Vigilância em Saúde https://orcid.org/0000-0002-1680-2310
  • Victor Bertollo Gomes Porto Secretaria de Vigilância em Saúde https://orcid.org/0000-0002-3112-6154
  • Ronaldo Fernandes Santos Alves Secretaria de Vigilância em Saúde https://orcid.org/0000-0002-8358-0519
  • Marcela Santos Correa Da Costa Secretaria de Vigilância em Saúde
  • Sandra Maria Deotti Carvalho Secretaria de Vigilância em Saúde
  • Greice Madeleine Ikeda do Carmo Secretaria de Vigilância em Saúde
  • Francieli Fontana Sutile Tardetti Fantinato Secretaria de Vigilância em Saúde https://orcid.org/0000-0002-0110-2266
  • Marcelo Yoshito Wada Secretaria de Vigilância em Saúde
  • Yluska Myrna Meneses Brandão e Mendes Secretaria de Vigilância em Saúde
  • Martha Gonçalves Vieira Secretaria de Atenção Primária à Saúde
  • Roselle Bugarin Steenhouwer Secretaria de Atenção Primária à Saúde https://orcid.org/0000-0002-3776-2979
  • Klebia Magalhães Pereira Castello Branco Sociedade Brasileira de Cardiologia
  • Maria Verônica Câmara dos Santos Sociedade Brasileira de Cardiologia
  • Ivan Romero Rivera Sociedade Brasileira de Cardiologia https://orcid.org/0000-0001-9473-132X
  • Luiz Henrique Nicoloso Sociedade Brasileira de Cardiologia
  • Marco Aurelio Palazzi Safadi Sociedade Brasileira de Pediatria https://orcid.org/0000-0002-4401-9446
  • Dalva Maria de Assis Sociedade Brasileira de Pediatria https://orcid.org/0000-0002-3102-7607

DOI:

https://doi.org/10.1590/s1679-49742021000400005

Keywords:

Coronavirus Infections, Pediatrics, Systemic Inflammatory Response, Syndrome, Death, Epidemiological Monitoring, Cross-Sectional Studies

Abstract

Objective: To describe the clinical-epidemiological profile of Multisystem Inflammatory Syndrome in Children (MIS-C) cases and to identify factors associated with MIS-C deaths in Brazil, 2020. Methods: Cross-sectional study, based on MIS-C national monitoring database in Brazil, 2020. Simple and multiple logistic regression was performed to estimate crude and adjusted odds ratios (OR). Results: The median age of cases (n=652) was 5 years, 57.1% were male, 52.0% were brown race/color and 6.4% died. The odds of death was greater among those who presented O2 saturation <95% (ORa=4.35 – 95%CI 1.69;11.20) and altered result of urea (ORa=5.18 – 95%CI 1.91;14.04); lower in the absence of cutaneous lesion such as rash (ORa=0.23 – 95%CI 0.09;0.62), with the use of anticoagulants (ORa=0.32 – 95%CI 0.12;0.89) and of immunoglobulins (ORa=0.38 – 95%CI 0.15;1.01). Conclusion: Fatality rates was higher among cases that presented O2 saturation<95% and altered urea, and lower among those with cutaneous lesion, who used immunoglobulins and anticoagulants.

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Posted

2021-09-20

Section

Health Sciences