Multisystem Inflammatory Syndrome in Children: sectional study of cases and factors associated with deaths during COVID-19 pandemic in Brazil, 2020
Keywords:Coronavirus Infections, Pediatrics, Systemic Inflammatory Response, Syndrome, Death, Epidemiological Monitoring, Cross-Sectional Studies
Objective: To describe the clinical-epidemiological profile of Multisystem Inflammatory Syndrome in Children (MIS-C) cases and to identify factors associated with MIS-C deaths in Brazil, 2020. Methods: Cross-sectional study, based on MIS-C national monitoring database in Brazil, 2020. Simple and multiple logistic regression was performed to estimate crude and adjusted odds ratios (OR). Results: The median age of cases (n=652) was 5 years, 57.1% were male, 52.0% were brown race/color and 6.4% died. The odds of death was greater among those who presented O2 saturation <95% (ORa=4.35 – 95%CI 1.69;11.20) and altered result of urea (ORa=5.18 – 95%CI 1.91;14.04); lower in the absence of cutaneous lesion such as rash (ORa=0.23 – 95%CI 0.09;0.62), with the use of anticoagulants (ORa=0.32 – 95%CI 0.12;0.89) and of immunoglobulins (ORa=0.38 – 95%CI 0.15;1.01). Conclusion: Fatality rates was higher among cases that presented O2 saturation<95% and altered urea, and lower among those with cutaneous lesion, who used immunoglobulins and anticoagulants.
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Copyright (c) 2021 Laís de Almeida Relvas-Brandt, Caroline Gava, Fernanda Sindeaux Camelo, Victor Bertollo Gomes Porto, Ronaldo Fernandes Santos Alves, Marcela Santos Correa Da Costa, Sandra Maria Deotti Carvalho, Greice Madeleine Ikeda do Carmo, Francieli Fontana Sutile Tardetti Fantinato, Marcelo Yoshito Wada, Yluska Myrna Meneses Brandão e Mendes, Martha Gonçalves Vieira, Roselle Bugarin Steenhouwer, Klebia Magalhães Pereira Castello Branco, Maria Verônica Câmara dos Santos, Ivan Romero Rivera, Luiz Henrique Nicoloso, Marco Aurelio Palazzi Safadi , Dalva Maria de Assis
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