Síndrome inflamatória multissistêmica pediátrica: estudo seccional dos casos e fatores associados aos óbitos durante a pandemia de COVID-19 no Brasil, 2020

Laís  de Almeida Relvas-Brandt; Caroline  Gava; Fernanda  Sindeaux Camelo; Victor   Bertollo Gomes Porto; Ronaldo  Fernandes Santos Alves; Marcela  Santos Correa Da Costa; Sandra  Maria Deotti Carvalho; Greice  Madeleine Ikeda do Carmo; Francieli  Fontana Sutile Tardetti Fantinato; Marcelo  Yoshito Wada; Yluska   Myrna Meneses Brandão e Mendes; Martha  Gonçalves Vieira; Roselle  Bugarin Steenhouwer; Klebia  Magalhães Pereira Castello Branco; Maria Verônica  Câmara dos Santos; Ivan  Romero Rivera; Luiz Henrique  Nicoloso; Marco Aurelio  Palazzi Safadi; Dalva  Maria de Assis

doi:10.1590/s1679-49742021000400005

##article.authors##

Laís de Almeida Relvas-Brandt Secretaria de Vigilância em Saúde https://orcid.org/0000-0003-1273-5445
Caroline Gava Secretaria de Vigilância em Saúde https://orcid.org/0000-0001-6287-1715
Fernanda Sindeaux Camelo Secretaria de Vigilância em Saúde https://orcid.org/0000-0002-1680-2310
Victor Bertollo Gomes Porto Secretaria de Vigilância em Saúde https://orcid.org/0000-0002-3112-6154
Ronaldo Fernandes Santos Alves Secretaria de Vigilância em Saúde https://orcid.org/0000-0002-8358-0519
Marcela Santos Correa Da Costa Secretaria de Vigilância em Saúde
Sandra Maria Deotti Carvalho Secretaria de Vigilância em Saúde
Greice Madeleine Ikeda do Carmo Secretaria de Vigilância em Saúde
Francieli Fontana Sutile Tardetti Fantinato Secretaria de Vigilância em Saúde https://orcid.org/0000-0002-0110-2266
Marcelo Yoshito Wada Secretaria de Vigilância em Saúde
Yluska Myrna Meneses Brandão e Mendes Secretaria de Vigilância em Saúde
Martha Gonçalves Vieira Secretaria de Atenção Primária à Saúde
Roselle Bugarin Steenhouwer Secretaria de Atenção Primária à Saúde https://orcid.org/0000-0002-3776-2979
Klebia Magalhães Pereira Castello Branco Sociedade Brasileira de Cardiologia
Maria Verônica Câmara dos Santos Sociedade Brasileira de Cardiologia
Ivan Romero Rivera Sociedade Brasileira de Cardiologia https://orcid.org/0000-0001-9473-132X
Luiz Henrique Nicoloso Sociedade Brasileira de Cardiologia
Marco Aurelio Palazzi Safadi Sociedade Brasileira de Pediatria https://orcid.org/0000-0002-4401-9446
Dalva Maria de Assis Sociedade Brasileira de Pediatria https://orcid.org/0000-0002-3102-7607

DOI:

https://doi.org/10.1590/s1679-49742021000400005

Keywords:

Coronavirus Infections, Pediatrics, Systemic Inflammatory Response, Syndrome, Death, Epidemiological Monitoring, Cross-Sectional Studies

Abstract

Objective: To describe the clinical-epidemiological profile of Multisystem Inflammatory Syndrome in Children (MIS-C) cases and to identify factors associated with MIS-C deaths in Brazil, 2020. Methods: Cross-sectional study, based on MIS-C national monitoring database in Brazil, 2020. Simple and multiple logistic regression was performed to estimate crude and adjusted odds ratios (OR). Results: The median age of cases (n=652) was 5 years, 57.1% were male, 52.0% were brown race/color and 6.4% died. The odds of death was greater among those who presented O₂ saturation <95% (ORa=4.35 – 95%CI 1.69;11.20) and altered result of urea (ORa=5.18 – 95%CI 1.91;14.04); lower in the absence of cutaneous lesion such as rash (ORa=0.23 – 95%CI 0.09;0.62), with the use of anticoagulants (ORa=0.32 – 95%CI 0.12;0.89) and of immunoglobulins (ORa=0.38 – 95%CI 0.15;1.01). Conclusion: Fatality rates was higher among cases that presented O₂ saturation<95% and altered urea, and lower among those with cutaneous lesion, who used immunoglobulins and anticoagulants.