CHARACTERISTICS AND RISK FACTORS FOR MORTALITY IN PATIENTS HOSPITALIZED BY COVID-19 IN A PUBLIC HOSPITAL IN TACNA
Keywords:COVID-19, viral pneumonia, coronavirus infections, mortality, Peru, colchicine
Objective: The objective of the study was to describe the clinical, laboratory and treatment characteristics of patients hospitalized for COVID-19 and to determine the risk factors for hospital mortality.
Methods: Retrospective cohort study of adult patients hospitalized for COVID-19. Clinical, laboratory and treatment data were extracted from the medical records of patients admitted to Level III Daniel Alcides Carrión-Tacna Hospital. Survival analysis used the Cox proportional hazards model and crude and adjusted hazard ratios (HR) were calculated with their respective 95% confidence intervals (95% CI).
Results: 351 patients were evaluated, 74.1% were men, the most common comorbidities were obesity (31.6%), hypertension (27.1%) and diabetes mellitus (24.5%). The median time of hospitalization was 8 days (IQR: 4-15). 32.9% died during follow-up. The multivariate analysis showed an increased risk of dying associated with age> = 65 years HR = 3.55 (95% CI: 1.70-7.40), increase in lactate dehydrogenase> 720 U / L HR = 2.08 (95% CI: 1.34-3.22), and oxygen saturation less than 90%, mainly when it was less than 80% RH = 4.07 (95% CI: 2.10-7.88). In addition, within the treatment, colchicine showed a protective effect HR = 0.46 (95% CI: 0.23-0.91).
Conclusions: Risk factors for mortality from COVID-19 included being older than 65 years, having oxygen saturation less than 90%, and elevated lactate dehydrogenase> 720 U / L; colchicine treatment could improve the prognosis of patients.
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Copyright (c) 2021 Miguel Hueda Zavaleta, Cesar Augusto Copaja Corzo, Fabrizzio Bardales Silva , Rodrigo Flores Palacios , Luis Barreto Rocchetti , Vicente Aleixandre Benites Zapata
This work is licensed under a Creative Commons Attribution 4.0 International License.