Caso Clínico Perforación Gástrica por AINES

Abstract

Gastric perforation is a serious and potentially fatal complication that can result prolonged or inappropriate use of non-steroidal anti-inflammatory drugs (NSAIDs). Los NSAIDs are medications commonly prescribed for pain relief and inflammation in various medical conditions, including arthritis and musculoskeletal injuries. Aunque son effective, its use is associated with a series of gastrointestinal, gastric perforation being one of the most severe. This event occurs due to ability of NSAIDs to inhibit the synthesis of prostaglandins, which play a role crucial in the protection of the gastric mucosa. Lack of prostaglandins leads to a reduction of the mucosal barrier, increasing the susceptibility of the stomach to action corrosive gastric acid, which can eventually result in ulceration and perforation. Patients with gastric perforation due to NSAIDs may experience acute abdominal pain y of sudden onset, and requires urgent medical intervention to avoid complications such as peritonitis and septic shock.