This preprint has been published elsewhere.
DOI of the published preprint https://doi.org/10.55684/2023.81.2.041
Preprint / Version 1

NRP1 AS A POTENTIAL MOLECULAR TARGET FOR MEDULOBLASTOMA

##article.authors##

  • Moisés Augusto de Araujo INCC - Instituto de Neurocirurgia e Cirurgia de Coluna, Bento Gonçalves, RS, Brasil
    • Paulo Afonso Nunes Nassif Faculdade Evangélica Mackenzie do Paraná https://orcid.org/0000-0002-1752-5837
      • Livia Fratini Laboratório de Câncer e Neurobiologia, Centro de Pesquisa Experimental, Hospital de Clínicas (CPE-HCPA), Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
        • Rafael Roesler Instituto Nacional de Ciência e Tecnologia de Biologia do Câncer Infantil e Oncologia Pediátrica – INCT BioOncoPed, Porto Alegre, RS, Brasil
          • Samuel Rabello Departamento de Medicina, Centro Universitário de Várzea Grande - UNIVAG, Cuiabá, MT, Brasil
            • Alexsandro Batista da Costa Carmo Hospital São Mateus, Cuiabá, MT, Brasil
              • Gustavo Rassier Isolan Centro de Neurologia e Neurocirurgia Avançada (CEANNE), Porto Alegre, RS, Brasil

                DOI:

                https://doi.org/10.1590/SciELOPreprints.8891

                Keywords:

                Neuropilin-1, NRP1, Medulloblastoma, Pediatric câncer, Brain tumor

                Abstract

                Introdução : O meduloblastoma é um tumor maligno, altamente agressivo e de rápido crescimento que surge no cerebelo ou no assoalho do quarto ventrículo e tronco encefálico, principalmente em crianças. Mesmo com os avanços na terapia, a morbidade e a mortalidade continuam sendo um grande desafio. Portanto, novos tratamentos são necessários para reduzir esses resultados.

                Objetivo : Revisar a relação NRP1 (neuropilina 1) e meduloblastoma como potencial alvo terapêutico e, também, com sobrevida global.

                Method: This is a narrative review carried out in the PubMed and Scielo databases. The search used the following keywords: “neuropilins, medulloblastoma, brain tumors, pediatrics”. The inclusion criteria were review articles, experimental studies, pre-clinical and clinical research, in English and Portuguese, and available in full text. The selected articles were analyzed based on the technologies covered, future perspectives and challenges mentioned, diseases mentioned and the central idea of the article.

                Result: 30 articles were included.

                Conclusion: Medulloblastomas have high transcriptional levels of neuropilin (NRP1) and their low levels are related to lower overall survival, especially in SHH. In this sense, NRP1 and its complex action system appear as a potential target for oncological therapies for brain tumors.

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                Posted

                05/09/2024

                How to Cite

                NRP1 AS A POTENTIAL MOLECULAR TARGET FOR MEDULOBLASTOMA. (2024). In SciELO Preprints. https://doi.org/10.1590/SciELOPreprints.8891

                Section

                Health Sciences

                Copyright (c) 2024 Moisés Augusto de Araujo, Paulo Afonso Nunes Nassif, Livia Fratini, Rafael Roesler , Samuel Rabello , Alexsandro Batista da Costa Carmo , Gustavo Rassier Isolan

                Creative Commons License

                This work is licensed under a Creative Commons Attribution 4.0 International License.

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                Data statement

                • The research data is contained in the manuscript