O OMENTO MAIOR PODE SER DOADOR DE CÉLULAS-TRONCO AO MIOCÁRDIO ISQUÊMICO?

Fernando Bermudez Kubrusly; Jurandir Marcondes Ribas Filho; Paulo Afonso Nunes Nassif; Douglas Mesadri Gewehr; João Lucchese Piovesan; Oscar Capistrano dos Santos; Geraldo Odilon do Nascimento-Filho; Luiz Fernando Kubrusly

doi:10.1590/SciELOPreprints.8812

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Fernando Bermudez Kubrusly Instituto Presbiteriano Mackenzie, São Paulo, SP, Brasil
Jurandir Marcondes Ribas Filho Faculdade Evangélica Mackenzie do Paraná
Paulo Afonso Nunes Nassif Instituto Presbiteriano Mackenzie, São Paulo, SP, Brasil https://orcid.org/0000-0002-1752-5837
Douglas Mesadri Gewehr Instituto Presbiteriano Mackenzie, São Paulo, SP, Brasil
João Lucchese Piovesan Instituto Presbiteriano Mackenzie, São Paulo, SP, Brasil
Oscar Capistrano dos Santos Hospital Jesus Pequenino, Bezerros, PE, Brasil
Geraldo Odilon do Nascimento-Filho Hospital Monte Sinai, Garanhuns, PE, Brasil
Luiz Fernando Kubrusly Instituto Presbiteriano Mackenzie, São Paulo, SP, Brasil

DOI:

https://doi.org/10.1590/SciELOPreprints.8812

Keywords:

Stem cell, Myocardial ischemia, Immunohistochemistry, CD34

Abstract

Introduction: Recent progress in the bioengineering of cardiac grafts offers a new therapeutic modality for the regeneration of cardiac tissue after myocardial infarction. CD34 is a marker that expresses all hematopoietic and endothelial precursor cells, and functions as a cell adhesion factor. The antibody corresponding to this marker is used in immunohistochemistry to evaluate the formation of new vessels and the presence of stem cells.

Objective: To evaluate the effectiveness of omentopexy in neovascularization and stem cells.

Methods: Review collecting information published on selected virtual platforms (SciELO – Scientific Electronic Library Online, Google Scholar, Pubmed and Scopus). The search began with descriptors related to the topic, identified through DeCS/MESH in the following: “myocardial ischemia; myocardial revascularization; omentopexy; immunohistochemistry; CD34; stem cells”. They were read by title and summary, with an AND or OR search followed by the full reading of those most closely related to the topic. A total of 23 articles were included.

Results: The greater omentum has a remarkable clinical property in containing sites of tissue damage. It increases its tissue volume in response to foreign and inflammatory particles involving several immunomodulatory cells with progenitor cells, in a process called “omentum activation”.

Conclusion: Cardio-omentopexy associated with mechanical abrasion and myocardial perforations proves to be efficient in inducing neovascularization. The greater omentum promotes stem cells - confirmed by CD34 -, demonstrating great potential as a future therapy to restore areas of ischemic myocardium.