MEMBRANA DE NANOCELULOSE COM FATOR DE CRESCIMENTO DO ENDOTÉLIO VASCULAR (VEGF): FUTURO NA CICATRIZAÇÃO DE QUEIMADURAS PROFUNDAS?

Nerlan Tadeu Gonçalves de Carvalho; Fernando Tabushi; Osvaldo Malafaia; Rafael Dib Possiedi; Jose Eduardo Ferreira Manso

doi:10.1590/SciELOPreprints.8446

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Nerlan Tadeu Gonçalves de Carvalho Instituto Presbiteriano Mackenzie, São Paulo, SP, Brasil
Fernando Tabushi Faculdade Evangélica Mackenzie do Paraná
Osvaldo Malafaia Instituto Presbiteriano Mackenzie, São Paulo, SP, Brasil https://orcid.org/0000-0002-1829-7071
Rafael Dib Possiedi University of Toronto
Jose Eduardo Ferreira Manso Universidade Federal do Rio de Janeiro

DOI:

https://doi.org/10.1590/SciELOPreprints.8446

Keywords:

Bacterial outer membrane proteins, Vascular endothelial growth factor, VEGFR, Biological dressings

Abstract

Introduction: Burns are injuries caused by various agents that promote the destruction of the skin and can lead to the exposure of deeper tissues. To make better use of this variety of treatment options, it is important to know its causes, extent and treatment methods.

Objective: Update the use of nanocellulose membranes with glycerol, vascular endothelial growth factor and other complements in burn healing.

Method: Review carried out with material and analysis selected from research on virtual platforms (SciELO, Google Scholar, Virtual Health Library, Pubmed and Scopus) using the descriptors: “bacterial membrane proteins; vascular endothelial growth factor; VEGFR; biological dressings; dressings” with AND or OR search, considering the title and/or abstract. Afterwards, the articles were read in full.

Result: 45 articles were included.

Conclusion: Although more research is needed, published studies show that the enrichment of nanocellulose membranes with some additives such as Vascular Endothelial Growth Factor VEGF) and incorporation of sensors that can monitor wound conditions will result in highly effective dressings. Considering the technological advances to produce low-cost membranes, associated with artificial intelligence and the efforts of researchers, the benefit to public health will soon be evident.