ARE GABRA5 MEMBRANE RECEPTORS MOLECULAR TARGETS IN THE IDENTIFICATION OF GLIOMAS?

Abstract

Introduction: Gliomas are the most common primary tumors of the central nervous system. The majority are formed by glioblastomas, with high degrees of proliferation and invasion, with biological heterogeneity and little response to current treatments. Immunotherapy and genetherapy have not shown efficacy and, therefore, it is necessary to seek knowledge of new molecules and genes involved in their carcinogenesis.

Objectives: To evaluate whether the alpha 5 gamma-aminobutyric acid receptor (GABRA5) is a potential therapeutic target or biomarker for gliomas of different subgroups, and the correlation between GABRA5 messenger ribonucleic acid (mRNA) levels and overall survival.

Methods: Integrative review carried out on virtual platforms in Portuguese and English, carried out using descriptors related to the topic, described in DeCS as “glioma, central nervous system, glioblastoma, GABA, GABRA5” with AND or OR search, initially considering the title and/or summary. Afterwards, in those that were most related to the topic, the texts were read in full.

Results: 36 articles were included.

Conclusion: GABRA5 mRNA levels in glioma samples from all histological subgroups are lower compared to control. No correlation was observed between GABRA5 mRNA levels and overall survival in the evaluated subgroups.