CORRELAÇÃO DA TROPONINA SANGUÍNEA E SALIVAR EM PACIENTES COM INFARTO AGUDO DO MIOCÁRDIO: ESTUDO PRELIMINAR

Flávia Kubrusly Arsego; Luiz Fernando Kubrusly; Douglas Mesadri Gewehr; Rafael Dib Possiedi; Paulo Afonso Nunes Nassif; Fernando Issamu Tabushi; Fernando Bermudez Kubrusly; Maria Luiza Ronkoski; Priscila Panassolo Cioato

doi:10.1590/SciELOPreprints.8347

##article.authors##

Flávia Kubrusly Arsego Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil
Luiz Fernando Kubrusly Faculdade Evangélica Mackenzie do Paraná
Douglas Mesadri Gewehr Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil
Rafael Dib Possiedi University of Toronto
Paulo Afonso Nunes Nassif Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil https://orcid.org/0000-0002-1752-5837
Fernando Issamu Tabushi Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil
Fernando Bermudez Kubrusly Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil
Maria Luiza Ronkoski Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil
Priscila Panassolo Cioato Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil

DOI:

https://doi.org/10.1590/SciELOPreprints.8347

Keywords:

Troponin I, Troponin T, Acute myocardial infarction

Abstract

Introduction: In the event of myocardial injury, the identification of biomarkers that constitute the cardiac muscle cell, especially troponins, can be observed from blood and saliva samples. The preference for using saliva as a diagnostic fluid is supported by the ease of obtaining it using a non-invasive and potentially pre-hospital method.

Objective: To verify the expression of troponin I in salivary fluid in acute myocardial infarction in emergency and pre-hospital screenings and correlate it with plasma troponin I levels.

Method: Cross-sectional analytical study of diagnostic testing in 27 patients, 9 women and 18 men, with diagnostic confirmation of acute myocardial infarction. Blood and saliva samples were collected and stored and transported over a period of up to 24 hours for troponina I quantification.

Results: The study demonstrated that 44.4% of patients were positive for troponin I in both analyses, with equal dichotomous results in 48.1% of cases. Thus, the salivary troponin test achieved 48% sensitivity and 50% specificity.

Conclusion: It was possible to identify troponin in the saliva fluid of patients suffering from acute myocardial infarction, but the probability of a false positive result was 50% and a false negative result was 52%.