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CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?

##article.authors##

  • Jander Moreira Monteiro Departamento de Neurocirurgia, Centro de Neurologia e Neurocirurgia Avançada (CEANNE)
    • Jaqueline Isadora Reis Ramos Universidade de São Paulo image/svg+xml
      • Ian Teixeira e Sousa Unidade de Terapia Intensiva Pediátrica, Hospital Infantil da Conceição, Porto Alegre, RS, Brasil
        • Rayana Longo Bighetti-Trevisan Universidade de São Paulo image/svg+xml
          • Jurandir Marcondes Ribas-Filho Programa de Pós-Graduação, Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil
            • Gustavo Rassier Isolan Faculdade Evangélica Mackenzie do Paraná
              • Paulo Afonso Nunes Nassif Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil https://orcid.org/0000-0002-1752-5837
                • José Fernando Polanski Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil

                  DOI:

                  https://doi.org/10.1590/SciELOPreprints.7717

                  Keywords:

                  Neurosurgery, Surgical oncology, Molecular targeted therapy, Medulloblastoma

                  Abstract

                  Introduction: Medulloblastomas are the most common solid tumors of childhood and many studies seek to develop new chemotherapy drugs by identifying genes whose expression is new molecular targets for drugs, such as membrane receptors associated with cell replication. Objective: To review existing knowledge about the association of CD114 expression with mortality in medulloblastoma. Method: Narrative review collecting information with material for reading and analysis selected from research on virtual platforms (SciELO, Pubmed and Scopus). Initially, a search was carried out for descriptors related to the topic, which were identified through MESH using the following terms: “neurosurgery, surgical oncology, molecular targeted therapy, medulloblastoma” with AND or OR search, considering the title and/or abstract. After, the search was carried out, the title and abstract were analyzed and those that could be included were read in full. Results: 23 articles were included. Conclusion: There is no direct relationship between the expression of the CD114 membrane receptor and mortality in patients with medulloblastoma, and additional studies should be carried out on the intracellular signaling pathways associated with this receptor and its gene, CSF3R

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                  Posted

                  12/15/2023

                  How to Cite

                  CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?. (2023). In SciELO Preprints. https://doi.org/10.1590/SciELOPreprints.7717

                  Section

                  Health Sciences

                  Copyright (c) 2023 Jander Moreira Monteiro, Jaqueline Isadora Reis Ramos , Ian Teixeira e Sousa, Rayana Longo Bighetti-Trevisan, Jurandir Marcondes Ribas-Filho, Gustavo Rassier Isolan, Paulo Afonso Nunes Nassif , José Fernando Polanski

                  Creative Commons License

                  This work is licensed under a Creative Commons Attribution 4.0 International License.

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                  Data statement

                  • The research data is contained in the manuscript