COVID-19 NATURAL HISTORY AND ITS THERAPEUTIC RELATIONSHIPS

Abstract

Objectives: Analyze the scientific production on COVID-19 and propose a schematic model on the natural history of COVID-19, according to its therapeutic relationships. Methods: Metasynthesis in the light of thinking about the natural history of the disease, comprising 40 research products selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes - PRISMA, through a search strategy limited to the PubMed^® database, operationalized in June 2020. Results: The study demonstrated that one of the first challenges faced in this pandemic is to understand the natural history of COVID-19 to guide the implementation of efficient therapeutic activities. Although the provision of specific diagnostic tests is essential for the diagnosis of COVID-19, the lack of them would not be a barrier if the knowledge about the natural history of the disease was not incomplete, since the natural history of the disease is known to be the sovereign evidence parameter in clinical diagnosis and in the implementation of an efficient treatment protocol. Conclusions: A differentiated understanding of the presentation of the natural history of COVID-19 can help to determine the appropriate time to initiate therapeutic interventions relevant to each of the three phases of evolution of COVID-19.