Kawasaki Disease and Covid-19 in Children: A Systematic Review

Abstract

Objective: To present scientific evidence based on a systematic literature review (PRISMA) evaluating the association of Kawasaki Disease and COVID-19 in children. Research Strategies: For the selection of studies, the combination based on the Medical Subject Heading Terms (MeSH) was used. The Medline (Pubmed), LILACS, SciELO, COCHRANE and BIREME databases were used. The search period for the articles comprised the last 10 years (2010 to 2020). Selection Criteria: The designs of the selected studies were descriptive, cross-sectional, cohort and case study, which had the title, abstract or body of the article in relation to the research objective. An evaluation of the quality of the articles was carried out, which included articles with a minimum score of 6 in the modified scale of the literature. Results: 840 articles with potential for inclusion were retrieved, with only one of them responding to the inclusion criteria and the guiding question. which consisted of assessing the association of Kawasaki Disease and COVID-19 in children.Conclusion: A significant increase in the incidence of Kawasaki-type diseases after the onset of the epidemic has been reported, suggesting an association between the COVID-19 epidemic and the high incidence of a severe form of KD. However, further studies are needed to investigate the correlation between these two diseases.