Biomarcadores salivales validados para el diagnóstico de cáncer gástrico: una revisión sistemática

Humberto Muñoz; Natalia Zuñiga; César Rivera

doi:10.1590/SciELOPreprints.3174

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Humberto Muñoz Escuela de Odontología, Facultad de Ciencias de la Salud, Universidad de Talca, Chile https://orcid.org/0000-0002-2546-0834
Natalia Zuñiga Escuela de Odontología, Facultad de Ciencias de la Salud, Universidad de Talca, Chile
César Rivera Universidad de Talca https://orcid.org/0000-0002-5491-4233

DOI:

https://doi.org/10.1590/SciELOPreprints.3174

Keywords:

Biomarkers, Saliva, Stomach Neoplasms

Abstract

In recent years, saliva has been shown to possess biomarkers capable of diagnosing different diseases, including gastric cancer. Here we present a systematic review (PROSPERO CRD42021259519) with the aim of evaluating biomarkers closer to clinical use. We identified markers of different molecular nature, of which 3 proteins stand out (CSTB, TPI1 and DMBT1), which in the validation stage presented high diagnostic accuracy. Salivary biomarkers have great potential for the detection of stomach cancer; however, it is recommended in subsequent studies to improve the design and execution phases of the research in order to obtain better quality evidence.