Effect of ozonated sunflower oil on dentin hypersensitivity after basic periodontal therapy: a pilot randomized split-mouth clinical trial

Abstract

Objective: To evaluate the effect of adjunctive ozonated sunflower oil on dentin hypersensitivity and periodontal clinical parameters following basic periodontal therapy. Material and method: This pilot randomized split-mouth clinical trial included ten systemically healthy patients presenting dentin hypersensitivity after supragingival scaling. In each participant, the two arches were randomly allocated to receive either adjunctive ozonated sunflower oil or no adjunctive treatment after basic periodontal therapy. Dentin hypersensitivity was assessed using a visual analog scale. Plaque index and gingival bleeding index were recorded at baseline and after seven days. Data were analyzed using paired-sample t-tests, adopting a significance level of 5%. Result: At the seven-day follow-up, the test arches treated with adjunctive ozonated sunflower oil exhibited significantly lower dentin hypersensitivity scores than the control arches (1.30 ± 0.95 vs. 3.00 ± 0.94; p < 0.001). Significant reductions were also observed in plaque index (34.00 ± 17.76 vs. 54.00 ± 20.11; p = 0.004) and gingival bleeding index (15.00 ± 15.09 vs. 36.00 ± 24.59; p = 0.010). Conclusion: Within the limitations of this pilot study, ozonated sunflower oil demonstrated the potential to reduce dentin hypersensitivity and improve clinical periodontal parameters following basic periodontal therapy. Further randomized clinical trials with larger sample sizes and longer follow-up periods are required to confirm these findings.