Tumor stem cells markers characterization in squamous cell carcinoma of oral cavity

Abstract

Squamous cell cancer of the oral cavity is a pathology with low survival rates for patients who suffer from it. It is suggested that this may be a consequence of its recurrence and resistance to treatment. It has been suggested that progenitor tumor cells due to their self-renewal, tumor initiation, migration and metastasis properties may be responsible for the maintenance and renewal of the tumor. However, there is still no consensus on the true participation of these cells and their identification and characterization is still an experimental challenge. In this study, it was possible to identify in situ, using fluorescence microscopy, different markers of progenitor tumor cells: Tumour-Related Antigen [TRA] -1-60, Stage- Specific Embryonic Antigen-4 [SSEA-4], SOX2, NANOG and OCT4, The presence of these markers suggests the participation of tumor progenitor cells in the evolution of this type of cancer, which opens up new therapeutic avenues for the possible treatment of this tumor in order to improve prognosis, survival rate and quality of life of the patient