THE HEMOPHAGOCYTIC LYMPHYSTIOCYTOSIS SECONDARY TO SYSTEMIC LUPUS WITH REFRACTORY MIS-C CLINIC IN CHILDREN: A CASE REPORT

Abstract

We report the case of an 11-year-old male adolescent, with symptoms of MISC-PIMS, negative RT-PCR and negative serology for COVID-19, family contact RT-PCR positive for COVID-19, treated in a referral hospital center, receiving treatment standardized for MIS-C, without response to initial therapy, despite receiving the same scheme on 3 occasions, classified as refractory, for which an expanded study was decided for other entities; finding hemophagocytic lymphohistiocytosis associated with systemic lupus erythematosus, an entity that often share similar inflammatory markers with the MISC, even usually confused with rheumatological, hematological and neoplastic entities, therefore the importance of reporting the case to identify this group refractory to treatment and identify another disease with expanded study, since it could be harmful or even fatal if a definitive diagnosis is not obtained.