Hipotermia cerebral seletiva prolongada no traumatismo cranioencefálico: evidências experimentais e implicações neurocirúrgicas

Amylcar Edemilson Dvilevicius; Allan Fernando Giovanini; Claudio Luciano Franck; Jose Fernando Polanski; Luiz Martins Collaço; Fernanda Marcondes Ribas; Felipe Salvagni Pereira; Gustavo Rassier Isolan

doi:10.1590/SciELOPreprints.15109

##article.authors##

Amylcar Edemilson Dvilevicius Colégio Brasileiro de Cirurgia Digestiva https://orcid.org/0000-0003-0162-4571
- Conceptualization
- Writing – Original Draft Preparation
Allan Fernando Giovanini Faculdade Evangélica Mackenzie do Paraná https://orcid.org/0000-0002-1637-2955
- Formal Analysis
- Writing – Review & Editing
Claudio Luciano Franck Faculdade Evangélica Mackenzie do Paraná https://orcid.org/0000-0002-4326-8109
- Conceptualization
- Writing – Review & Editing
Jose Fernando Polanski Faculdade Evangélica Mackenzie do Paraná https://orcid.org/0000-0003-3151-2327
- Formal Analysis
- Writing – Original Draft Preparation
Luiz Martins Collaço Faculdade Evangélica Mackenzie do Paraná
- Conceptualization
- Writing – Review & Editing
Fernanda Marcondes Ribas Faculdade Evangélica Mackenzie do Paraná https://orcid.org/0000-0003-4010-2717
- Conceptualization
- Writing – Original Draft Preparation
Felipe Salvagni Pereira Faculdade Evangélica Mackenzie do Paraná https://orcid.org/0000-0003-2634-6176
- Formal Analysis
- Writing – Review & Editing
Gustavo Rassier Isolan Faculdade Evangélica Mackenzie do Paraná https://orcid.org/0000-0002-7863-0112
- Supervision
- Project Administration

DOI:

https://doi.org/10.1590/SciELOPreprints.15109

Keywords:

Traumatic brain injury, Hypothermia, Selective hypothermia, Decompressive craniectomy

Abstract

Introduction: Traumatic brain injury is one of the major health and socioeconomic problems impacting societies worldwide. Objective: To review the literature regarding the effectiveness of prolonged selective hypothermia (for 12 hours) associated with decompressive craniectomy in the treatment of traumatic brain injury. Method: An integrative review was conducted by collecting data from online platforms. Initially, a search was performed using DEC descriptors related to the topic, using the following terms: "traumatic brain injury; hypothermia; selective hypothermia; decompressive craniotomy" with AND or OR search, considering the title and/or abstract, and the selected articles were read in full. The material for reading and analysis was selected from the SciELO, Google Scholar, PubMed, and Scopus platforms. Result: Considering only those with the greatest relevance to the topic, 73 articles were included. Conclusion: The results obtained from the experiments encourage the development of new studies with longer exposure times to hypothermia, around 24 hours, and with analyses of the action of selective hypothermia in relation to inflammatory markers and chemokines. This proposal should provide more relevant information about the effective benefits of this therapy.