PODEM OS ANESTÉSICOS LOCAIS AJUDAR NO PROCESSO CICATRICIAL DAS FERIDAS CIRÚRGICAS?

Márcio Grande Carstens; Jurandir Marcondes Ribas Filho; Claudio Luciano Franck; Nicolau Gregori Czeczko; Marcos Fabiano Sigwalt; Ronaldo Mafia Cuenca; Nelson Adami Andreollo; Jose Eduardo Ferreira Manso; Fernando Issamu Tabushi; Matheus Toniolo Malafaia

doi:10.1590/SciELOPreprints.7987

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Márcio Grande Carstens Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil
Jurandir Marcondes Ribas Filho Faculdade Evangélica Mackenzie do Paraná https://orcid.org/0000-0002-5251-7672
Claudio Luciano Franck Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil
Nicolau Gregori Czeczko Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil
Marcos Fabiano Sigwalt Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil
Ronaldo Mafia Cuenca Universidade de Brasília
Nelson Adami Andreollo Universidade Estadual de Campinas (UNICAMP)
Jose Eduardo Ferreira Manso Universidade Federal do Rio de Janeiro
Fernando Issamu Tabushi Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil
Matheus Toniolo Malafaia Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brasil

DOI:

https://doi.org/10.1590/SciELOPreprints.7987

Keywords:

Local anesthetics, Healing, Neovascularization, Collagen

Abstract

Introduction: Evaluating the scarring differences between areas previously anesthetized with different local anesthetics is interesting to verify whether the choice of anesthetic helps in surgical healing in relation to inflammation, neovascularization and collagen deposition.

Objectives: Review the existing literature with a focus on analyzing the role of local anesthetics in aiding the healing of surgical wounds.

Method: Narrative review of literature selected from the SciELO – Scientific Electronic Library Online, Google Scholar, Pubmed and Scopus platforms. Initially, the review searched for keywords in the focus of the research, based on MESH/DeCS with the following terms: “local anesthetics, healing, neovascularization, collagen” with AND or OR search, considering the title and/or abstract. Next, only those that were most related to the topic were included, and the texts were read for inclusion.

Results: 73 articles were included, read and interpreted focusing on the role of anesthetics in healing, pain, side effects and the best that currently emerge in analgesia and scar potential.

Conclusions: No differences were observed between the anesthetics studied in terms of healing, inflammation and neovascularization. However, there was a significant difference in the production of collagens with an intensity of 6 to 12 times greater than collagen types I, II and III with the use of levobupivacaine.