Biological, social, and healthcare factors associated with death due to influenza A(H1N1) during the 2009 epidemic in Brazil
DOI:
https://doi.org/10.1590/SciELOPreprints.6696Keywords:
influenza a virus, h1n1 subtype, Disease outbreak, risk factors, case-control studiesAbstract
Background: In June 2009, the World Health Organization (WHO) raised the global alert level for the A(H1N1)pdm09 influenza pandemic and at that time sustained transmission in Brazil was established. It was urgent to carry out studies that evaluated possible risk factors for death from Influenza A(H1N1) to improve case management strategies to reduce the lethality of the disease. This study aimed to identify risk factors for death from Influenza A(H1N1), including the effectiveness of the vaccine against influenza A(H1N1) concerning mortality. Methods: A case-control of incident cases of influenza A(H1N1) reported in the Epidemiological Information Systems of the states of São Paulo, Paraná, Pará, Amazonas, and Rio Grande do Sul was conducted. Results: 305 participants were included, 70 of them cases and 235 controls, distributed as follows: Amazonas – 9 cases/10 controls, Pará – 22 cases/77 controls, São Paulo – 19 cases/49 controls, Paraná – 10 cases/54 controls, Rio Grande do Sul – 10 cases/45 controls. These participants had a mean age of 30 years, with 33 years among cases and 25 years among controls. There was a predominance of females both among cases and controls. Biological (age), pre-existing diseases (congestive heart failure, respiratory disease, and diabetes mellitus), and care factors (ICU admission) associated with death from Influenza A(H1N1) were identified. Conclusion: The risk factors identified in this investigation allowed subsidizing the elaboration of clinical conducts, but also indicate important aspects for facing “new” influenza epidemics that are likely to occur in our country.
Downloads
Metrics
Posted
How to Cite
Section
Copyright (c) 2023 Jose Ueleres Braga, Ana Freitas Ribeiro

This work is licensed under a Creative Commons Attribution 4.0 International License.
Plaudit
Funding data
-
Ministério da Saúde
Grant numbers Convenio 728336/200
Data statement
-
The research data cannot be made publicly available
- The research data are under the responsibility of the researcher who guaranteed that the secrecy and confidentiality indicated in the approval of the research ethics committee will be respected.