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Neurological complications in patients with SARS-CoV-2 infection: a systematic review

##article.authors##

  • Renato Puppi Munhoz University of Toronto, Toronto Western Hospital, Movement Disorders Centre, Toronto ON https://orcid.org/0000-0002-4783-4067
  • José Luiz Pedroso Universidade Federal de São Paulo, Escola Paulista de Medicina, Department of Neurology and Neurosurgery, São Paulo SP, Brazil.
  • Fábio Augusto Nascimento Baylor College of Medicine, Department of Neurology, Houston TX, USA.
  • Sergio Monteiro de Almeida Universidade Federal do Paraná, Hospital de Clínicas, Neuroinfection Outclinic, Virology Laboratory, Medical Pathology Department, Curitiba PR, Brazil
  • Orlando Graziani Povoas Barsottini Universidade Federal de São Paulo, Escola Paulista de Medicina, Department of Neurology and Neurosurgery, São Paulo SP, Brazil
  • Francisco Eduardo Cardoso Universidade Federal de Minas Gerais, Hospital das Clínicas, Movement Disorders Unit, Neurology Service, Internal Medicine Department, Belo Horizonte MG, Brazil
  • Hélio A Ghizoni Teive Universidade Federal do Paraná, Hospital de Clínicas, Internal Medicine Department, Neurology Service, Curitiba PR, Brazil

DOI:

https://doi.org/10.1590/0004-282X20200051

Keywords:

Coronavirus Infections, COVID-19, Neurology, Guillain-Barré Syndrome, Encephalitis, Stroke

Abstract

Background: As the COVID-19 pandemic unfolds worldwide, different forms of reports have described its neurologic manifestations. Objective: To review the literature on neurological complications of SARS-CoV-2 infection. Methods: Literature search performed following systematic reviews guidelines, using specific keywords based on the COVID-19 neurological complications described up to May 10th, 2020. Results: A total of 43 articles were selected, including data ranging from common, non-specific symptoms, such as hyposmia and myalgia, to more complex and life-threatening conditions, such as cerebrovascular diseases, encephalopathies, and Guillain-Barré syndrome. Conclusion: Recognition of neurological manifestations of SARS-CoV-2 should be emphasized despite the obvious challenges faced by clinicians caring for critical patients who are often sedated and presenting other concurrent systemic complications.

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Posted

2020-05-15

Section

Health Sciences