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IMMUNOHISTOCHEMICAL ANALYSIS OF THE EXPRESSION OF ALCAM AND ALDH1 MARKERS IN PATIENTS WITH COLORRETAL ADENOCARCINOMA AND ASSOCIATION WITH CLINICOPATHOLOGICAL OUTCOMES

##article.authors##

  • Cecilia Neves de Vasconcelos Faculdade Evangélica Mackenzie do Paraná
  • Carmen Australia Paredes Marcondes Ribas Faculdade Evangélica Mackenzie do Paraná
  • Rodrigo Ketzer Krebs Faculdade Evangélica Mackenzie do Paraná
  • Ana Maria Waaga-Gasser Brigham and Women's Hospital image/svg+xml
  • Martin Gasser Faculdade Evangélica Mackenzie do Paraná
  • Nicolau Gregori Czeczko Faculdade Evangélica Mackenzie do Paraná
  • Osvaldo Malafaia Colégio Brasileiro de Cirurgia Digestiva https://orcid.org/0000-0002-1829-7071

DOI:

https://doi.org/10.1590/SciELOPreprints.4208

Keywords:

ALCAM, ALDH1, Colorectal cancer

Abstract

Background: Colorectal cancer has a high global mortality and tumor markers have emerged as diagnostic, management and prognostic indicators. New markers are being studied. Objective: To verify if there is a correlation between the immunohistochemical expression of ALCAM and ALDH1 proteins in colorectal adenocarcinoma tissue with epidemiological and clinicopathological characteristics, in particular their impact on disease progression and death. Method: Observational, single-center, analytical, retrospective study, through the investigation of patients undergoing surgical resection for colorectal cancer. 122 patients were evaluated. Regarding progression, it was shown that in individuals with positive ALCAM (n=40), 14/40 (35%) had progression, and for positive ALDH (n=54), 22/54 (40.7%). For death, the analysis of ALCAM positive (n=40), 24/40 (60%) died, and ALDH1 positive (n=54), 33/54 (61.1%). Conclusion: The immunohistochemical expression of ALCAM and ALDH1 markers was not associated with disease progression and death; it was also not possible to observe a correspondence relationship with the evaluated markers.

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Posted

06/01/2022

How to Cite

Vasconcelos, C. N. de, Ribas, C. A. P. M., Krebs, R. K., Waaga-Gasser, A. M., Gasser, M., Czeczko, N. G., & Malafaia, O. (2022). IMMUNOHISTOCHEMICAL ANALYSIS OF THE EXPRESSION OF ALCAM AND ALDH1 MARKERS IN PATIENTS WITH COLORRETAL ADENOCARCINOMA AND ASSOCIATION WITH CLINICOPATHOLOGICAL OUTCOMES. In SciELO Preprints. https://doi.org/10.1590/SciELOPreprints.4208

Section

Health Sciences

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