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COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE

##article.authors##

  • Giovanna Santos Piedade Faculdade Evangélica Mackenzie do Paraná
  • Cynthia Fontoura Klas Faculdade Evangélica Mackenzie do Paraná
  • Rebeca Loureiro Rebouças Faculdade Evangélica Mackenzie do Paraná
  • Gleyce Rodrigues da Costa Farias Faculdade Evangélica Mackenzie do Paraná
  • Isabelle Guth Faculdade Evangélica Mackenzie do Paraná
  • Luiz Martins Collaço Faculdade Evangélica Mackenzie do Paraná
  • Camila Moraes Marques Faculdades Pequeno Principe
  • Luiz Fernando Kubrusly Faculdade Evangélica Mackenzie do Paraná https://orcid.org/0000-0002-6546-9841

DOI:

https://doi.org/10.1590/SciELOPreprints.4142

Keywords:

Liver cirrhosis, Experimental, Thioacetamide, Coconut oil

Abstract

Background: Prevention of the progression of cirrhosis with dietary supplementation has been in focus Coconut oil has been suggested. Objective: To evaluate the effect of coconut oil supplementation in cirrhotic rats. Method: Forty Wistars were divided: control (CO), control + coconut oil (CO + OC), thioacetamide (TAA) and thioacetamide + coconut oil (TAA + OC). TAA was added to water for 13 weeks and coconut oil was administered by gavage. Blood, liver, muscle and nervous tissue samples were obtained for laboratory and histopathological analyses. Results: AST, ALT, total cholesterol, HDL, LDL, triglycerides were not statistically significant. In histology, even without differences, there was a tendency towards significance regarding the proliferation of bile ducts, fibrotic septa and muscle fiber atrophy between the TAA and TAA + OC groups. Conclusion: No significant protective effect of coconut oil on liver disease was found.

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Posted

05/20/2022

How to Cite

Piedade, G. S., Klas, C. F., Rebouças, R. L., Farias, G. R. da C., Guth, I., Collaço, L. M., Marques, C. M., & Kubrusly, L. F. (2022). COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE. In SciELO Preprints. https://doi.org/10.1590/SciELOPreprints.4142

Section

Health Sciences
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