Preprint has been published in a journal as an article
DOI of the published article https://doi.org/10.1590/0001-3765202020200408
Preprint / Version 1

Schinopsis brasiliensis Engl. to combat the biofilm-dependents diseases in vitro

##article.authors##

  • Pedro Sette-de-Souza Faculdade de Odontologia, Universidade de Pernambuco - Rua Cicero Monteiro de Melo, s/n, São Cristóvão, 56503-146, Arcoverde/PE, Brasil; Programa de Pós-Graduação em Saúde e Desenvolvimento Socioambiental (PPGSDS), Universidade de Pernambuco, Garanhuns/PE, Brasil; Laboratório de Desenvolvimento e Ensaios de Medicamentos, Centro de Ciências Biológicas e da Saúde, Universidade Estadual da Paraíba - Rua Baraúnas, s/n, Universitários, 58429-500, Campina Grande/PB, Brasil https://orcid.org/0000-0001-9119-8435
  • Cleildo Pereira de Santana Centro de Tecnologia em Desenvolvimento de Medicamentos, Faculdade de Farmácia, Universidade Federal de Minas Gerais - Avenida Antônio Carlos, 6627, Pampulha, 31270-010, Belo Horizonte/MG, Brasil
  • Ilza Maria de Oliveira Sousa Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, Universidade de Campinas - Rua Alexandre Cazellato, 999, Betel, 13140-000, Paulinia/SP, Brasil
  • Mary Ann Foglio Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, Universidade de Campinas - Rua Alexandre Cazellato, 999, Betel, 13140-000, Paulinia/SP, Brasil; Faculdade de Ciências Farmacêuticas, Universidade de Campinas - Rua Cândido Portinari, 200, Cidade Universitária, 13083-871, Campinas/SP, Brasil
  • Francinalva Dantas Medeiros Faculdade de Ciências Farmacêuticas, Universidade de Campinas - Rua Cândido Portinari, 200, Cidade Universitária, 13083-871, Campinas/SP, Brasil
  • Ana Cláudia Dantas de Medeiros Laboratório de Desenvolvimento e Ensaios de Medicamentos, Centro de Ciências Biológicas e da Saúde, Universidade Estadual da Paraíba - Rua Baraúnas, s/n, Universitários, 58429-500, Campina Grande/PB, Brasil; Departamento de Ciências Farmacêuticas, Universidade Estadual da Paraíba - Rua Baraúnas, s/n, Universitários, 58429-500, Campina Grande/PB, Brasil

DOI:

https://doi.org/10.1590/SciELOPreprints.386

Keywords:

Antibacterial Agents, Natural Products, Oral diseases, Schinopsis brasiliensis

Abstract

Dental caries and periodontal disease are the most prevalent of the biofilm-dependent diseases. With numerous side effects on the use of chlorhexidine, the search for new safe therapeutic alternatives for microorganisms involved with these diseases increases every day. This study aimed to evaluate the antimicrobial activity and cytotoxicity of extracts made from the bark of Schinopsis brasiliensis Engl. against five oral microorganisms and analyze their phytochemical and thermal degradation profile. The liquid-liquid partition was performed with hexane, chloroform and ethyl acetate. The identification and quantification of the chemical marker was done. Antimicrobial activity was evaluated based on the minimum inhibitory concentration. The cytotoxicity was analyzed based on the hemolysing potential of the samples. The thermal degradation profile was performed by two different methods. Gallic acid was identified as the main compound of the samples and showed the highest amount in the chloroform fraction. All samples were able to inhibit the growth of the microorganisms tested and showed no cytotoxicity. The ethanol extract absorbs less heat than the fractions. All samples exhibited exothermic peak consistent with degradation of gallic acid. Based on the results, the samples used are potential candidates for use in dental formulations for biofilm control.

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Posted

05/09/2020

How to Cite

Sette-de-Souza, P., Santana, C. P. de, Sousa, I. M. de O., Foglio, M. A., Medeiros, F. D., & Medeiros, A. C. D. de. (2020). Schinopsis brasiliensis Engl. to combat the biofilm-dependents diseases in vitro. In SciELO Preprints. https://doi.org/10.1590/SciELOPreprints.386

Section

Health Sciences

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