Pharmacological interventions for COVID-19: Protocol for a Rapid Living Systematic Review with network meta-analysis
Keywords:Network Meta-analysis, drug therapy, coronavirus infections, systematic review
CONTEXT AND OBJECTIVE: Coronavirus disease 2019 (COVID-19) has emerged in China in December 2019 and rapidly spread. Although extraordinary efforts have been made on research regarding pharmacological interventions, none have proven effective. This is the protocol for a rapid living systematic review that aims to compare the effectiveness and safety of different pharmacological interventions for the treatment of COVID-19. METHODS: rapid living systematic review methodology with Network Meta-Analysis following the recommendations of Cochrane Handbook. We will include randomized controlled trials (RCT) and quasi-RCTs that evaluate single and/or combined pharmacological interventions at any dose for the treatment of COVID-19. We will search Medline via PubMed, Embase via Elsevier, Cochrane Library - Cochrane Central Register of Controlled Trials (CENTRAL), Portal Regional BVS - LILACS, Scopus and WebofScience to identify potentially eligible studies. No language restrictions will be used in the selection. We will perform the critical appraisal of included studies with the Risk of Bias tool and the certainty of evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE).
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Copyright (c) 2020 Maria Eduarda dos Santos Puga, Ana Carolina Pereira Nunes Pinto, Aline Pereira da Rocha, Keilla Martins Milby, César Ramos Rocha-Filho, Felipe Sebastião de Assis Reis, Nelson Carvas Junior, Vinicius Tassoni Civile, Rodolfo Rodrigo Pereira Santos, Giulia Fernandes Moça Trevisani, Laura Jantsch Ferla, Gabriel Sodré Ramalho, Maria Eduarda dos Santos Puga, Virgínia Fernandes Moça Trevisani, Alvaro Nagib Atallah
This work is licensed under a Creative Commons Attribution 4.0 International License.