Pharmacological interventions for COVID-19: Protocol for a Rapid Living Systematic Review with network meta-analysis

Maria Eduarda dos Santos Puga; Ana Carolina Pereira Nunes Pinto; Aline Pereira da Rocha; Keilla Martins Milby; César Ramos Rocha-Filho; Felipe Sebastião de Assis Reis; Nelson Carvas Junior; Vinicius Tassoni Civile; Rodolfo Rodrigo Pereira Santos; Giulia Fernandes Moça Trevisani; Laura Jantsch Ferla; Gabriel Sodré Ramalho; Maria Eduarda dos Santos Puga; Virgínia Fernandes Moça Trevisani; Alvaro Nagib Atallah

doi:10.1590/SciELOPreprints.348

##article.authors##

Maria Eduarda dos Santos Puga Universidade Federal de São Paulo. Centro Cochrane do Brasil https://orcid.org/0000-0001-8470-861X
Ana Carolina Pereira Nunes Pinto MSc, Physiotherapist, PhD Student., Evidence-Based Health Program, Universidade Federal de São Paulo (UNIFESP); Professor, Biological and Health Sciences Department, Universidade Federal do Amapá (AP), Brazil and Volunteer Researcher, Cochrane Brazil, São Paulo (SP), Brazil. https://orcid.org/0000-0002-1505-877X
Aline Pereira da Rocha Pharmacist, PhD Student, Evidence-Based Health Program, Universidade Federal de São Paulo (UNIFESP) and Volunteer Researcher, Cochrane Brazil, São Paulo (SP), Brazil https://orcid.org/0000-0002-0863-6500
Keilla Martins Milby Nurse, PhD Student, Evidence-Based Health Program, Universidade Federal de São Paulo (UNIFESP) and Volunteer Researcher, Cochrane Brazil, São Paulo (SP), Brazil. https://orcid.org/0000-0003-0601-457X
César Ramos Rocha-Filho https://orcid.org/0000-0002-7190-0263
Felipe Sebastião de Assis Reis MD, MPS, Technologies and Healthcare. Manager, Medical Practices, Beneficência Portuguesa de São Paulo. https://orcid.org/0000-0002-5728-4863 VI Physical Educator. Ibirapuera University https://orcid.org/0000-0002-5728-4863
Nelson Carvas Junior Physical Educator. Ibirapuera University
Vinicius Tassoni Civile MSc, Physiotherapist, PhD Student, Evidence-Based Health Program, Universidade Federal de São Paulo (UNIFESP); Assistant Professor, Physiotherapy Course, Paulista University and Volunteer Researcher, Cochrane Brazil, São Paulo (SP), Brazil https://orcid.org/0000-0002-1718-6281
Rodolfo Rodrigo Pereira Santos Statistician. MSc Student, Evidence-Based Health Program, Universidade Federal de São Paulo (UNIFESP). Data Science Manager, Synova Health CRO https://orcid.org/0000-0003-1540-7586
Giulia Fernandes Moça Trevisani Undergraduate Medical Student at Universidade Santo Amaro, São Paulo (SP), https://orcid.org/0000-0003-3581-3047
Laura Jantsch Ferla Undergraduate Medical Student at Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil https://orcid.org/0000-0002-8162-2068
Gabriel Sodré Ramalho Undergraduate Medical Student, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil. https://orcid.org/0000-0001-7201-2308
Maria Eduarda dos Santos Puga Librarian .Universidade Federal de São Paulo. Centro Cochrane do Brasil. Information Specilaist Brazilian Cochrane Centre https://orcid.org/0000-0001-8470-861X
Virgínia Fernandes Moça Trevisani MD, MSc, PhD Rheumatologist. Discipline of Emergency and Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil
Alvaro Nagib Atallah MD, MSc, PhD. Nephrologist and Full Professor, Discipline of Emergency and Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), and Director, Cochrane Brazil, São Paulo (SP), Brazil

DOI:

https://doi.org/10.1590/SciELOPreprints.348

Keywords:

Network Meta-analysis, drug therapy, coronavirus infections, systematic review

Resumo

CONTEXT AND OBJECTIVE: Coronavirus disease 2019 (COVID-19) has emerged in China in December 2019 and rapidly spread. Although extraordinary efforts have been made on research regarding pharmacological interventions, none have proven effective. This is the protocol for a rapid living systematic review that aims to compare the effectiveness and safety of different pharmacological interventions for the treatment of COVID-19. METHODS: rapid living systematic review methodology with Network Meta-Analysis following the recommendations of Cochrane Handbook. We will include randomized controlled trials (RCT) and quasi-RCTs that evaluate single and/or combined pharmacological interventions at any dose for the treatment of COVID-19. We will search Medline via PubMed, Embase via Elsevier, Cochrane Library - Cochrane Central Register of Controlled Trials (CENTRAL), Portal Regional BVS - LILACS, Scopus and WebofScience to identify potentially eligible studies. No language restrictions will be used in the selection. We will perform the critical appraisal of included studies with the Risk of Bias tool and the certainty of evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE).