DOI of the published article https://doi.org/10.1590/2236-8906-111/2020
Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)
Keywords:acetylcholinesterase, dermatophytes, phytochemistry, natural products, free radicals
The objective of this work was to evaluate the chemical profile, total phenol content and the antioxidant, antiacetylcholinesterase and antifungal activities of ethanol extracts from leaves (EEF) and stem (EEC) of five species of Senna, as well as to evaluate the correlation between the content of total phenols with the DPPH free radical scavenging activity and with the inhibition of the acetylcholinesterase AChEI enzyme. The phytochemical test showed the presence of secondary metabolites in all extracts. The EEF and EEC of Senna trachypus, stood out for presenting the highest values of total phenols. S. trachypus EEF and EEC showed the best action on the acetylcholinesterase enzyme. All species showed antioxidant activity, especially the EEF from S. trachypus. A strong correlation was observed for the variables total phenols and antioxidant activity (r = -0.71), very strong for total phenols and anti-acetylcholinesterase (r = -0.84) and moderate activity for antioxidant and anti-acetylcholinesterase activity (r = 0.43). Only S. trachypus extracts showed activity against all dermatophytes, when compared to the other species. The species S. trachypus was considered the most promising plant for further studies, in order to find compounds with pharmacological actions.
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Copyright (c) 2022 Andréa Maria Neves, Selene Maia de Morais, Hélcio Silva dos Santos, Marcílio Matos Ferreira, Ricardo Carneiro Vera Cruz, Elnatan Bezerra de Souza, Lúcia Betânia da Silva Andrade, Raquel Oliveira dos Santos Fontenelle
This work is licensed under a Creative Commons Attribution 4.0 International License.