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DOI of the published article https://doi.org/10.1590/2236-8906-111/2020
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Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)

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DOI:

https://doi.org/10.1590/2236-8906-111/2020

Keywords:

acetylcholinesterase, dermatophytes, phytochemistry, natural products, free radicals

Abstract

The objective of this work was to evaluate the chemical profile, total phenol content and the antioxidant, antiacetylcholinesterase and antifungal activities of ethanol extracts from leaves (EEF) and stem (EEC) of five species of Senna, as well as to evaluate the correlation between the content of total phenols with the DPPH free radical scavenging activity and with the inhibition of the acetylcholinesterase AChEI enzyme. The phytochemical test showed the presence of secondary metabolites in all extracts. The EEF and EEC of Senna trachypus, stood out for presenting the highest values of total phenols. S. trachypus EEF and EEC showed the best action on the acetylcholinesterase enzyme. All species showed antioxidant activity, especially the EEF from S. trachypus. A strong correlation was observed for the variables total phenols and antioxidant activity (r = -0.71), very strong for total phenols and anti-acetylcholinesterase (r = -0.84) and moderate activity for antioxidant and anti-acetylcholinesterase activity (r = 0.43). Only S. trachypus extracts showed activity against all dermatophytes, when compared to the other species. The species S. trachypus was considered the most promising plant for further studies, in order to find compounds with pharmacological actions.

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Posted

01/10/2022

How to Cite

Neves, A. M., Morais, S. M. de, Santos, H. S. dos, Ferreira, M. M., Cruz, R. C. V., Souza, E. B. de, Andrade, L. B. da S., & Fontenelle, R. O. dos S. (2022). Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae). In SciELO Preprints. https://doi.org/10.1590/2236-8906-111/2020

Section

Biological Sciences

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