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Supplementation of prebiotics and probiotics in autistic children: integrative review




autism, probiotics, prebiotics, supplementation


Objective: To evaluate the use of probiotics and prebiotics supplementation in autistic children. Data source: Articles were identified in the PubMed and SciELO databases. In order to locate the studies, descriptors in English obtained from the Health Sciences Descriptors (DeCS), were used: Prebiotics. Probiotics. Autism Spectrum Disorder. Gut microbiota. Bifidobacterium. The search was limited to articles in Portuguese and English and comprised the years of publication between 2015-2021. Data synthesis: A total of 6 clinical trials conducted on children with autism have been systematically reviewed. Regarding the types of supplements used, there were 3 studies that used probiotics, 2 that used prebiotics and probiotics and 1 that made only the use of prebiotics. Despite the scarce amount of studies, they have had remarkable results in relation to the supplementation of probiotics and prebiotics in children with ASD. In some studies, it was possible to observe an improvement in the severity of autism and improvements in relation to antisocial behavior, while in others, there was an increase in beneficial bacteria and a decrease in pathogens in the gastrointestinal tract, leading to an improvement in recurrent gastrointestinal symptoms. Conclusions: It is noticeable that the use of prebiotics and probiotics can promote several benefits for people with autism, however studies with a larger number of individuals are necessary and there are standards regarding the intervention regimes.


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Author Biographies

Thaynara Lays Sales Brandão, Faculdade de Comunicação, Tecnologia e Turismo de Olinda - FACOTTUR

Busca de dados, síntese de dados, escrita, formatação, criação de tabela
e figuras presentes no artigo.

Júlia Carolina Lopes Silva, Universidade Federal de Pernambuco

Busca de dados, síntese de dados, escrita, formatação.

Jakeline Olindina Francelino, Universidade Federal de Pernambuco

Busca de dados, síntese de dados, revisão final e escrita do documento.


08/05/2021 — Updated on 01/03/2022



Health Sciences