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FACTORS ASSOCIATED WITH MORTALITY IN PATIENTS HOSPITALIZED WITH COVID-19: PROSPECTIVE COHORT AT EDGARDO REBAGLIATI MARTINS NATIONAL HOSPITAL. LIMA, PERU

##article.authors##

  • MIGUEL ANGEL VENCES Hospital Nacional Edgardo Rebagliati Martins,Essalud.Lima https://orcid.org/0000-0002-8538-6242
  • Juan José Pareja Ramos Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima
  • Paula Otero Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima
  • Liz E. Veramendi-Espinoza Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima
  • Melissa Vega-Villafana Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima
  • Julissa Mogollón-Lavi Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima
  • Eduardo Morales Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima
  • Josseline Olivera-Vera Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima
  • Carol Meza Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima
  • Lucia Salas Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima
  • Andy Triveño Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima
  • Renzo Marin Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima
  • Ricardo Carpio-Rodriguez Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima
  • Jessica Hanae Zafra Tanaka Universidad Peruana Cayetano Heredia - CRONICAS Centro de Excelencia en Enfermedades Crónicas - Lima - Perú.

DOI:

https://doi.org/10.1590/SciELOPreprints.1241

Keywords:

Coronavirus, COVID-19, SARS-CoV-2, mortality, hospitalization, risk factors, Peru

Abstract

Aim: To determine the associated factors with mortality of adult patients hospitalized with COVID-19.

Methods: We conducted a prospective cohort study and included patients older than 18 years hospitalized with the diagnosis of SARS-CoV-2 infection. Those patients with a positive rapid serological test on admission, but no respiratory symptoms nor compatible images were excluded. We collected the data from clinical records.

Results: A total of 813 adults were included, 544 (66.9%) with confirmed COVID-19. The mean age was 61.2 years (SD: 15.0) and 575 (70.5%) were male. The most frequent comorbidities were hypertension (34.1%) and obesity (25.9%). The most frequent symptoms on admission were dyspnea (82.2%) and cough (53.9%). A total of 114 (14.0%) patients who received mechanical ventilation, 38 (4.7%) were admitted to the Intensive Care Unit (ICU) and 377 (46.4%) died. The requirement for ventilatory support, greater lung involvement, comorbidities, and inflammatory markers were associated with mortality. It was found that for every 10 - year increase in age, the risk of dying increased by 32% (RR: 1.32 95% CI: 1.25 to 1.38). Those who required admission to the ICU and mechanical ventilation had 1.39 (95% CI: 1.13 to 1.69) and 1.97 (95% CI: 1.69 to 2.29) times the risk of dying compared to those who did not.

Conclusion:  We found a high mortality rate in hospitalized patients associated with greater age, more elevated inflammatory markers, and more severe respiratory compromise.

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Posted

09/24/2020

How to Cite

VENCES, M. A., Pareja Ramos, J. J., Otero , P. ., Veramendi-Espinoza, L. E. . ., Vega-Villafana, M. ., Mogollón-Lavi, J. ., Morales, E., Olivera-Vera, J. ., Meza, C., Salas, L., Triveño, A., Marin, R., Carpio-Rodriguez, R., & Zafra Tanaka, J. H. (2020). FACTORS ASSOCIATED WITH MORTALITY IN PATIENTS HOSPITALIZED WITH COVID-19: PROSPECTIVE COHORT AT EDGARDO REBAGLIATI MARTINS NATIONAL HOSPITAL. LIMA, PERU. In SciELO Preprints. https://doi.org/10.1590/SciELOPreprints.1241

Section

Health Sciences

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