FACTORS ASSOCIATED WITH MORTALITY IN PATIENTS HOSPITALIZED WITH COVID-19: PROSPECTIVE COHORT AT EDGARDO REBAGLIATI MARTINS NATIONAL HOSPITAL. LIMA, PERU
Keywords:Coronavirus, COVID-19, SARS-CoV-2, mortality, hospitalization, risk factors, Peru
Aim: To determine the associated factors with mortality of adult patients hospitalized with COVID-19.
Methods: We conducted a prospective cohort study and included patients older than 18 years hospitalized with the diagnosis of SARS-CoV-2 infection. Those patients with a positive rapid serological test on admission, but no respiratory symptoms nor compatible images were excluded. We collected the data from clinical records.
Results: A total of 813 adults were included, 544 (66.9%) with confirmed COVID-19. The mean age was 61.2 years (SD: 15.0) and 575 (70.5%) were male. The most frequent comorbidities were hypertension (34.1%) and obesity (25.9%). The most frequent symptoms on admission were dyspnea (82.2%) and cough (53.9%). A total of 114 (14.0%) patients who received mechanical ventilation, 38 (4.7%) were admitted to the Intensive Care Unit (ICU) and 377 (46.4%) died. The requirement for ventilatory support, greater lung involvement, comorbidities, and inflammatory markers were associated with mortality. It was found that for every 10 - year increase in age, the risk of dying increased by 32% (RR: 1.32 95% CI: 1.25 to 1.38). Those who required admission to the ICU and mechanical ventilation had 1.39 (95% CI: 1.13 to 1.69) and 1.97 (95% CI: 1.69 to 2.29) times the risk of dying compared to those who did not.
Conclusion: We found a high mortality rate in hospitalized patients associated with greater age, more elevated inflammatory markers, and more severe respiratory compromise.
How to Cite
Copyright (c) 2020 MIGUEL ANGEL VENCES, Juan José Pareja Ramos, Paula Otero , Liz E. Veramendi-Espinoza, Melissa Vega-Villafana, Julissa Mogollón-Lavi, Eduardo Morales, Josseline Olivera-Vera, Carol Meza, Lucia Salas, Andy Triveño, Renzo Marin, Ricardo Carpio-Rodriguez, Jessica Hanae Zafra Tanaka
This work is licensed under a Creative Commons Attribution 4.0 International License.